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Brief Profile

Salvatore Rinaldi,

  • Graduated in medicine from the University of Chieti, Italy;
  • Specialized in Sports Medicine from the University of Chieti, Italy;
  • Neuro physio pathologist
  • Master's degree in Neuro Psycho Physical Pathology and in Neuro Psycho Physical Optimization from the University of Rome Tor Vergata.

Current positions

  • Co-founder and president of IRF Rinaldi Fontani Institute, Florence, Italy
  • Co-founder and scientific director of IRF Shanghai Medical Science Co., Ltd - Shanghai, China
  • Professor at the PhD School of the
    Biomedical Sciences Department of the University of Sassari, Italy

  • Vice President of the Italian Society of Neuro Psycho Physical Optimization (SONC)
  • Contract Professor in Postural Optimization - School of Specialization in Occupational Medicine - University of Florence, Italy

Since 1989 lecturer in University Master's degree courses, Postgraduate courses and Specialization Schools inAdaptive Neuro Physical Pathology and Neuro Psycho Physical Optimization at the Faculties of Medicine and Surgery of Chieti, Rome Tor Vergata, University of Palermo, University of Magna Graecia and University of Florence.

Associated editor of the International Journal of Energy & Technology.
Speaker at national and international conferences.
In his research he has established four international patents on Radio Electric Conveyed Fields (REAC)
Technology and on modulation of cellular reprogramming through REAC Technology.
He also defined a national patent for a measuring instrument for functional anatomical misalignment.

Publications on international journals indexed in PubMed

Radio electric asymmetric conveyer neuromodulation in depression, anxiety, and stress. Rinaldi A, Rinaldi C, Coelho Pereira JA, Lotti Margotti M, Bittencourt MN, Barcessat ARP, Fontani V, Rinaldi S. Neuropsychiatric Disease and Treatment 2019:15 469–480.

Physical stimulation by REAC and BMP4/WNT-1 inhibitor synergistically enhance cardiogenic commitment in iPSCs. Basoli V, Santaniello S,Rinaldi S, Fontani V, Pigliaru G, Wieser M, Strajeriu A, Castagna A, Redl H, Ventura C, Grillari R, Maioli M.
PLoS One. 2019 Jan 23;14(1):e0211188. doi: 10.1371/journal.pone.0211188. eCollection 2019.

Radio Electric Asymmetric Conveyer (REAC) technology to obviate loss of T cell responsiveness under simulated microgravity. Rinaldi S, Meloni MA, Galleri G, Maioli M, Pigliaru G, Cugia G, Santaniello S, Castagna A, Fontani V. PLoS One. 2018 Jul 6;13(7):e0200128. doi: 10.1371/journal.pone.0200128. eCollection 2018.

REAC neuromodulation treatments in subjects with severe socioeconomic and cultural hardship in the Brazilian state of Pará: a family observational pilot study. Coelho Pereira JA, Rinaldi A, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2018 Apr 16;14:1047-1054.
doi: 10.2147/NDT.S161646. eCollection 2018.

Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. Panaro MA, Aloisi A, Nicolardi G, Lofrumento DD, De Nuccio F, La Pesa V, Cianciulli A, Rinaldi R, Calvello R, Fontani V, Rinaldi S. Neurosci Bull. 2017 Nov 10. doi: 10.1007/s12264-017-0188-0.

REAC technology as optimizer of stallion spermatozoa liquid storage. Berlinguer F, Pasciu V, Succu S, Cossu I, Caggiu S, Addis D, Castagna A, Fontani V, Rinaldi S, Passino ES. Reprod Biol Endocrinol. 2017 Feb 8;15(1):11. doi: 10.1186/s12958-017-0229-6.

REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model. Lorenzini L, Giuliani A, Sivilia S, Baldassarro VA, Fernandez M, Margotti ML, Giardino L, Fontani V, Rinaldi S, Calzà L. Sci Rep. 2016 Nov 18;6:37483. doi: 10.1038/srep37483.

REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence. Maioli M, Rinaldi S, Pigliaru G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C. Sci Rep. 2016 Jun 24;6:28682.

Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids.Maioli M, Basoli V, Santaniello S, Cruciani S, Delitala AP, Pinna R, Milia E, Grillari-Voglauer R, Fontani V, Rinaldi S, Muggironi R, Pigliaru G, Ventura C. Stem Cells Int. 2016;2016:2056416. doi: 10.1155/2016/2056416. Epub 2016 Jan 10.

Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions. Zippo AG, Rinaldi S, Pellegata G, Caramenti GC, Valente M, Fontani V, Biella GE. Sci Rep. 2015 Dec 11;5:18200. doi: 10.1038/srep18200.

Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson's disease. Maioli M, Rinaldi S, Migheli R, Pigliaru G, Rocchitta G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C, Serra PA. Sci Rep. 2015 May 15;5:10439. doi: 10.1038/srep10439.

Radio electric asymmetric conveyer: a novel neuromodulation technology in Alzheimer's and other neurodegenerative diseases. Rinaldi S, Calzà L, Giardino L, Biella GE, Zippo AG, Fontani V. Front Psychiatry. 2015 Feb 17;6:22. doi: 10.3389/fpsyt.2015.00022

Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways. Rinaldi S, Maioli M, Pigliaru G, Castagna A, Santaniello S, Basoli V, Fontani V, Ventura C. Sci Rep. 2014 Sep 16;4:6373. doi: 10.1038/srep06373.

Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study. Rinaldi S, Mura M, Castagna A, Fontani V. Sci Rep. 2014 Jul 11;4:5668. doi: 10.1038/srep05668.

Motor Effects of Radio Electric Asymmetric Conveyer in Alzheimer's Disease: Results from a Cross-Over Trial. Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, Martínez-Martín P. J Alzheimers Dis. 2014 May 30.

Amniotic fluid stem cells morph into a cardiovascular lineage: analysis of a chemically induced cardiac and vascular commitment. Margherita Maioli, Giovanni Contini, Sara Santaniello, Pasquale Bandiera, Gianfranco Pigliaru, Raimonda Sanna, Salvatore Rinaldi, Alessandro P Delitala, Andrea Montella, Luigi Bagella,Carlo VenturaDrug Design, Development and Therapy 2013 Volume 2013:7 Pages 1063 - 1073

Radio electric asymmetric conveyed fields and human adipose-derived stem cells obtained with a non-enzymatic method and device: a novel approach to multipotency. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Bianchi F, Tremolada C, Fontani V, Ventura C.
Cell Transplant. 2013 Aug 30. doi: 10.3727/096368913X672037. [Epub ahead of print]

Effects of regenerative radioelectric asymmetric conveyer treatment on human normal and osteoarthritic chondrocytes exposed to IL-1β. A biochemical and morphological study. Collodel G, Fioravanti A, Pascarelli NA, Lamboglia A, Fontani V, Maioli M, Santaniello S, Pigliaru G, Castagna A, Moretti E, Iacoponi F, Rinaldi S, Ventura C.Clin Interv Aging. 2013;8:309-16. doi: 10.2147/CIA.S42229. Epub 2013 Mar 19.

Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Delitala A, Lotti Margotti M, Bagella L, Fontani V, Ventura C. Age (Dordr). 2013 May 9. [Epub ahead of print]

Motor Effects of REAC in Advanced Alzheimer's Disease: Results From a Pilot Trial. Olazarán J, González B, López J, Castagna A, Osa-Ruiz E, Herrero-Cano V, Agüera-Ortiz L, Rinaldi S, Martínez-Martín P. J Alzheimers Dis. 2013 Apr 19. [Epub ahead of print]

Physical reparative treatment in reptiles. Rinaldi S, Iannaccone M, Magi GE, Costantini E, Castagna A, Sanna Passino E, Maioli M, Fontani V.
BMC Vet Res. 2013 Feb 26;9(1):39. [Epub ahead of print]

The effect of radio electric asymmetric conveyer treatment on sperm parameters of subfertile stallions: a pilot study. Collodel G, Rinaldi S, Moretti E, Fontani V, Castagna A, Iacoponi F, Terzuoli G, Cubeddu F, Careddu GM, Cossu I, Passino ES. Reprod Biol. 2012 Nov;12(3):277-84. doi: 10.1016/j.repbio.2012.09.007. Epub 2012 Oct 22.

Radio Electric Conveyed Fields Directly Reprogram Human Dermal-Skin Fibroblasts Towards Cardiac-, Neuronal-, and Skeletal Muscle-Like Lineages. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Cavallini C, Fontani V, Ventura C. Cell Transplant. 2012 Oct 2. doi: 10.3727/096368912X657297. [Epub ahead of print]

Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study. Rinaldi S, Maioli M, Santaniello S, Castagna A, Pigliaru G, Gualini S, Margotti ML, Carta A, Fontani V, Ventura C. Clin Interv Aging. 2012;7:191-4. Epub 2012 Jun 29.

Preliminary pilot fMRI study of neuropostural optimization with a noninvasive asymmetric radioelectric brain stimulation protocol in functional dysmetria. Mura M, Castagna A, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2012;8:149-54. Epub 2012 Apr 4.

Neuropsychophysical optimization by REAC technology in the treatment of: sense of stress and confusion. Psychometric evaluation in a randomized, single blind, sham-controlled naturalistic study. Fontani V, Aravagli L, Margotti ML, Castagna A, Mannu P, Rinaldi S. Patient Prefer Adherence. 2012;6:195-9. Epub 2012 Mar 19.

Noninvasive radioelectric asymmetric conveyor brain stimulation treatment improves balance in individuals over 65 suffering from neurological diseases: pilot study. Fontani V, Rinaldi S, Castagna A, Margotti ML. Ther Clin Risk Manag. 2012;8:73-8. Epub 2012 Feb 17.

Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline. Fontani V, Mannu P, Castagna A, Rinaldi S. Patient Prefer Adherence. 2011;5:581-6. Epub 2011 Nov 22.

Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study. Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Patient Prefer Adherence. 2011;5:575-80. Epub 2011 Nov 18.

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study. Rinaldi S, Fontani V, Castagna A. Neuropsychiatr Dis Treat. 2011;7:649-54. Epub 2011 Oct 28.

Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study. Fontani V, Rinaldi S, Aravagli L, Mannu P, Castagna A, Margotti ML. Int J Gen Med. 2011;4:681-6. Epub 2011 Sep 22.

Radio Frequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool For Improving Tissue Regeneration. Maioli M, Rinaldi S, Santaniello S, Castagna A, Pigliaru G, Gualini S, Fontani V, Ventura C. Cell Transplant. 2011 Sep 22. doi: 10.3727/096368911X600966. [Epub ahead of print]

Radioelectric asymmetric stimulation of tissues as treatment for post-traumatic injury symptoms. Fontani V, Castagna A, Mannu P, Rinaldi S. Int J Gen Med. 2011;4:627-34. Epub 2011 Aug 26.

Radio electric tissue optimization in the treatment of surgical wounds. Castagna A, Fontani V, Rinaldi S, Mannu P. Clin Cosmet Investig Dermatol. 2011;4:133-7. Epub 2011 Aug 25.

Radioelectric brain stimulation in the treatment of generalized anxiety disorder with comorbid major depression in a psychiatric hospital: a pilot study. Olivieri EB, Vecchiato C, Ignaccolo N, Mannu P, Castagna A, Aravagli L, Fontani V, Rinaldi S. Neuropsychiatr Dis Treat. 2011;7:449-55. Epub 2011 Aug 4.

Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor. Mannu P, Rinaldi S, Fontani V, Castagna A. Neuropsychiatr Dis Treat. 2011;7:373-9. Epub 2011 Jun 15.

Radio electric asymmetric brain stimulation in the treatment of behavioral and psychiatric symptoms in Alzheimer disease. Mannu P, Rinaldi S, Fontani V, Castagna A. Clin Interv Aging. 2011;6:207-11. Epub 2011 Jul 26.

Comparison of two treatments for coxarthrosis: local hyperthermia versus radio electric asymmetrical brain stimulation. Castagna A, Rinaldi S, Fontani V, Mannu P, Margotti ML. Clin Interv Aging. 2011;6:201-6. Epub 2011 Jul 25.

Radioelectric asymmetric brain stimulation and lingual apex repositioning in patients with atypical deglutition. Castagna A, Rinaldi S, Fontani V, Mannu P. J Multidiscip Healthc. 2011;4:209-13. Epub 2011 Jun 21.

Stress-related psycho-physiological disorders: randomized single blind placebo controlled naturalistic study of psychometric evaluation using a radio electric asymmetric treatment. Rinaldi S, Fontani V, Aravagli L, Mannu P, Castagna A, Margotti ML, Rosettani B. Health Qual Life Outcomes. 2011 Jul 19;9:54.

Psychological and symptomatic stress-related disorders with radio-electric treatment: psychometric evaluation. Rinaldi S, Fontani, V., Aravagli, L., Lotti Margotti, M. Stress and Health. 2010;26(5):350-358.

A new approach on stress-related depression & anxiety: Neuro-Psycho- Physical-Optimization with Radio Electric Asymmetric-Conveyer. Rinaldi S, Fontani V, Moretti E, Rosettani B, Aravagli L, Saragò G, Collodel G. Indian J Med Res. 2010 Aug;132:189-94.

Does osteoarthritis of the knee also have a psychogenic component? Psycho-emotional treatment with a radio-electric device vs. intra-articular injection of sodium hyaluronate: an open-label, naturalistic study. Castagna A, Rinaldi S, Fontani V, Aravagli L, Mannu P, Margotti ML. Acupunct Electrother Res. 2010;35(1-2):1-16.

Psychometric evaluation of a radio electric auricular treatment for stress related disorders: a double-blinded, placebo-controlled controlled pilot study. Rinaldi S, Fontani V, Aravagli L, Mannu P. Health Qual Life Outcomes. 2010 Mar 20;8:31.

Radio electric treatment vs. Es-Citalopram in the treatment of panic disorders associated with major depression: an open-label, naturalistic study.
Mannu P, Rinaldi S, Fontani V, Castagna A, Margotti ML. Acupunct Electrother Res. 2009;34(3-4):135-49.

Effect of emotional stress on sperm quality. Collodel G, Moretti E, Fontani V, Rinaldi S, Aravagli L, Saragò G, Capitani S, Anichini C. Indian J Med Res. 2008 Sep
Rinaldi Fontani Institute - Viale Belfiore 43, 50144 Florence - Phone +39 055 290307 -
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